Toskani - Bioregenerative aesthetics

ToskaniMed - Bioregenerative aesthetic medecine

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    Skin Architect Fillers

    Facial fillers with cross-linked hyaluronic acid
    For professional use only

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    Sterile, pyrogen-free injectable gels, composed of cross-linked sodium hyaluronate of non-animal origin in phosphate-buffered saline solution.

    Administration by authorized healthcare professionals.

    The unique Hyasep technology preserves the structure of very high molecular weight hyaluronic acid (3000 KDa) throughout the manufacturing process, preventing its thermal degradation. This ensures that its unique properties and benefits are maintained. Resulting in:
    Maximum biocompatibility:
    It is the hyaluronic acid most similar to the one naturally found in our skin.
    Maximum biocompatibility:
    It is the hyaluronic acid most similar to the one naturally found in our skin.
    Bio-stimulation and tissue regeneration:
    Ability to act at the level of fibroblasts and adipocytes, promoting tissue regeneration.
    Bio-stimulation and tissue regeneration:
    Ability to act at the level of fibroblasts and adipocytes, promoting tissue regeneration.
    Collagen and elastin stimulation:
    Maximum capacity to induce the synthesis of elastin and collagen, restoring the architecture of the extracellular matrix.
    Collagen and elastin stimulation:
    Maximum capacity to induce the synthesis of elastin and collagen, restoring the architecture of the extracellular matrix.
    Balanced duration of the result:
    Prolonged effect with a time-compensated duration.
    Balanced duration of the result:
    Prolonged effect with a time-compensated duration.
    Ultrapure hyaluronic acid:
    Obtaining a highly purified AH thanks to its unique characteristics, optimizing its quality and clinical profile.
    Ultrapure hyaluronic acid:
    Obtaining a highly purified AH thanks to its unique characteristics, optimizing its quality and clinical profile.
    Low crosslinking and high security:
    Very low degree of crosslinking along with minimal levels of BDDE, ensuring an excellent safety profile.
    Low crosslinking and high security:
    Very low degree of crosslinking along with minimal levels of BDDE, ensuring an excellent safety profile.
    Long-term security and stability:
    High long-term sustainability with reduced risk of late complications such as migration, nodules, or granulomas.
    Long-term security and stability:
    High long-term sustainability with reduced risk of late complications such as migration, nodules, or granulomas.
    Developed according to high standards of quality and purity, this technology provides a favorable profile of biocompatibility, stability, and safety, supported by its physicochemical characteristics.

    SUBLIME, VOLUME, AND DENSITY

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    Skin Architect Sublime Filler

    Facial Volume Correction

    Composition: 20 mg/mL cross-linked sodium hyaluronate

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    Skin Architect Filler Density

    Structural correction and volume restoration
    Composition:     23 mg/mL cross-linked sodium hyaluronate

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    Skin Architect Filler Volume

    Facial volume restoration
    Composition:     26 mg/mL cross-linked sodium hyaluronate

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    Three HA concentrations for a comprehensive treatment approach

    *The image is for illustrative purposes only and does not replace the indications, contraindications, or implantation diagrams described in each product's IFU.

    An intelligent and versatile portfolio designed to address all treatment indications:

    Its safety profile is associated with the high purity of the raw material, strict control of the manufacturing process, and its balanced rheological properties, which enable appropriate tissue integration and the achievement of natural-looking results.
    Common product features
    • Cross-linked hyaluronic acid of non-animal origin
    • Sterile gel, pyrogen-free
    • Viscoelastic, transparent, colorless, and biodegradable
    • Latex-free
    • 1.0 mL syringe with ±0.020 mL accuracy
    Clinical use
    • Injection performed by a doctor authorized according to local regulations
    • Requires knowledge of the anatomy of the area to be treated
    • Injection technique and depth depend on the area and the product
    Recommended volume

    Approximately up to 2 mL per application point (as per medical assessment)

    Natural filler effect

    Regenerative action on facial adipose tissue

    The low cross-linking degree of Skin Architect Fillers could be associated with a shorter product persistence.

    The Skin Architect Filler line, thanks to its very high molecular weight hyaluronic acid, is designed to compensate for this effect through a biological and regenerative approach to the tissue.

    Its capacity for hypodermis regeneration promotes the stimulation of preadipocyte differentiation into adipocytes and an increase in lipid content within the adipocytes.

    Therefore, it promotes the regeneration of facial fat compartments, whose size decreases during the aging process or with abrupt weight loss.

    Highly sustainable long-lasting effect

    Prolonged increase in adipose tissue volume, compensating for the progressive degradation of hyaluronic acid without the need to increase its cross-linking degree or product excesses. The visual effect of biological filler due to the regeneration of fatty tissue persists longer than hyaluronic acid itself in the tissue.

    Security Study

    IL-8 Quantification to Determine Anti-inflammatory Activity

    Hyaluronic acid of 3000KDa has anti-inflammatory capacity, reducing post-treatment inflammation associated with the injection technique.

    Information for healthcare professionals

    Skin Architect Filler products should be used exclusively according to their complete instructions for use.
    A thorough clinical evaluation of the patient is recommended, and the risks and benefits should be considered in each case.
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    Request more information

    For additional information about Skin Architect Fillers or to address clinical questions related to their use, you can contact us.

    Contact for more information